Drug discovery and development is a time consuming and expensive process., taking about 10 years and costing about US 1.0 B dollars. Several candidates that enter clinical trials fail because of several reasons. Computer assisted drug design can speed up the process, reduce surprises and predict the properties, thereby reduce the cost of R&D. The course will cover structure and target based design, molecular modeling, quantum mechanics, drug likeness properties, QSAR and pharmacokinetic and dynamics using several softwares that are freely available.
INTENDED AUDIENCE
Biotech/Pharmaceuticals/Bioinformatics /Chemistry and allied programmes and research scientists in biotechnology and pharma industries and clinicians/medical practioners
PREREQUISITES
Prior knowledge of biochemistry, bioinformatics
INDUSTRY SUPPORT
Pharmaceutical industries/Biopharma/biotech
ABOUT THE INSTRUCTOR
Mukesh Doble:Professor at the department of Biotechnology at IIT Madras. Has previously worked in Imperial chemical Industries(ICI) and General Electric(GE) for 20 years . Areas of research are Biomaterials, Biopolymers and Drug design. Published 270 papers and 10 books and filed 10 patents (including two US). Has delivered on line video courses in Downstream processes and Biostatistics.
Additional information
Institute
IIT Madras
Total hours
20
Certification Process
1. Join the course
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COURSE ENROLMENT FEE: The Fee for Enrolment is Rs. 2000 + GST
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3. Get qualified to register for exams
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CRITERIA TO GET A CERTIFICATE
Assignment score = Score more than 50% in at least 6/8 assignments.
Exam score = 50% of the proctored certification exam score out of 100
Only the e-certificate will be made available. Hard copies will not be dispatched.”
4. Register for exams
The certification exam is conducted online with remote proctoring. Once a learner has become eligible to register for the certification exam, they can choose a slot convenient to them from what is available and pay the exam fee. Schedule of available slot dates/timings for these remote-proctored online examinations will be published and made available to the learners.
EXAM FEE: The remote proctoring exam is optional for a fee of Rs.1500 + GST. An additional fee of Rs.1500 will apply for a non-standard time slot.
5. Results and Certification
After the exam, based on the certification criteria of the course, results will be declared and learners will be notified of the same. A link to download the e-certificate will be shared with learners who pass the certification exam.
CERTIFICATE TEMPLATE
Course Details
Week 1 : Introduction to drug discovery Week 2 : Structure and property Week 3 : ADME-rules Week 4 : Force field/MM/QM Week 5 : Boundary conditions/Conformation Week 6 : QSAR/Pharmacophore Week 7 : Enzymes/proteins structures/docking Week 8 : PK/PD
BOOKS AND REFERENCES:
Voit E (2012) A First Course in Systems Biology. Garland Science, 1/e. ISBN 0815344678 • Klipp E (2009) Systems biology: a textbook. Wiley-VCH, 1/e. ISBN 9783527318742 • Newman MEJ (2011) Networks: an introduction. Oxford Univ. Press. ISBN 9780199206650
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